Purpose: To determine early intraocular pressure (IOP) changes after PARS PLANA VITRECTOMY and evaluate the related factors.Patients and methods: In a clinical trial, the study was performed on 105 eyes of 105 patients who underwent PARS PLANA VITRECTOMY. The patients were divided into four major groups: silicone oil-injected (63 patients), simple VITRECTOMY (16 patients), sulfur hexafluoride-injected (13 patients), and air-injected (13 patients). Preoperative and six consecutive post operative IOP measurements were done with apPLANAtion tonometer.Results: Considering all patients, mean preoperative IOP was 11.53 mmHg which increased by 8.85 after surgery, and maximum elevation occured 16 hours after the surgery. In the four study groups, mean IOP elevation was 11.94, 3.26, 6.64 and 2.58 mmHg, respectively and maximum IOP was recorded at 2-4, 6-8, 16, 24, 36, and 48 hours postoperatively. Post operative IOP increased to 21 mmHg or more in 66.7% of the patients. Factors associated with post VITRECTOMY IOP elevation included intraoperative silicone oil injection, SF6 injection, scleral buckling and development of fibrin in the anterior chamber postoperatively. Conclusion: IOP elevation is very commonly seen after PARS PLANA VITRECTOMY, especially in silicone oil and SF6-injected patients. The optimal time for detecting the pressure rise differs with the type of substitutes injected at the conclusion of operation. Measuring the IOP in the above conditions is compulsory.